Scientists have discovered a molecular “switch” that may explain why some people benefit from aerobic exercise and strength training, while others do not. Using both animal and human subjects, researchers discovered that a protein called C-Jun N-terminal kinase (JNK) helps to determine our response to exercise. If JNK is activated during exercise, it stimulates skeletal muscle growth. If it’s not activated, muscles will improve their adaptation for endurance and aerobic capacity. Further research is needed to determine JNK’s implications in the prevention of cardiovascular disease and its possible role in building muscle to fight muscle-wasting diseases.
Nature Communications, August 2018