Long-Term Opioid Use and Depression.
Long-Term Opioid Use and Depression.
Recent studies show more than 200 million prescriptions for opioid analgesics were issued in 2009 in the United States. Data on over 50,000 patients reveals that those on opioids for 180 days or longer have a 53% increased risk of developing major depression.
Journal of General Internal Medicine, November 2013