Alcohol and Acetaminophen.
There were 116,395 new kidney failures, 571,414 people living with kidney failure, and 90,118 deaths from the disease in the United States in 2009. Moderate or light consumption of alcohol taken with acetaminophen may increase the risk of kidney dysfunction. Acetaminophen usage and low to moderate alcohol consumption are not considered as individual risk factors for kidney damage, but together, they increase a person’s risk for kidney damage by 123%.
Mayo Clinic, November 2013